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| Emery,Flávio da S.; Silva,Raphael S.F.; Moura,Kelly C.G. de; Pinto,Maria C.F.R.; Amorim,Mauro B.; Malta,Valéria R.S.; Santos,Regina H.A.; Honório,Kátia M.; Silva,Albérico B.F. da; Pinto,Antonio V.. |
| The reaction of naphthoquinone-oximes (3) and (4) with diazomethane yields directly, in one step, the oxazoles (5) and (6), respectively. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinones; Oximes; Diazomethane; Oxazoles. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100004 |
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| FUTURO,DÉBORA O.; FERREIRA,PATRICIA G.; NICOLETTI,CAROLINE D.; BORBA-SANTOS,LUANA P.; SILVA,FERNANDO C. DA; ROZENTAL,SONIA; FERREIRA,VITOR FRANCISCO. |
| ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinones; Xanthenes; Lapachol; Lawsone; Candida spp; Disc diffusion method. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187 |
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| Costa-Lotufo,L.V.; Ferreira,M.A.D.; Lemos,T.L.G.; Pessoa,O.D.L.; Viana,G.S.B.; Cunha,G.M.A.. |
| Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Auxemma oncocalyx; Quinones; Sea urchin eggs; Oncocalyxone A. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800010 |
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